Formulation and Evaluation of a Moringa oleifera-Based Herbal Cream for Accelerated Wound Repair.
Emmanuel Chinedum Ibezim1, Mumuni Audu Momoh1*, Philip Dinebari Berebon2, Jacob Okwuchukwu Onyechi3, Ogochukwu Ngozi Chidimma Umeh3, Patrick Ndubuisi Onyi2, Edwin Ogechukwu Omeje4, Peter Ikechukwu5, Nnenna Ekpereka Ibezim6, Chinenye Patience Ugwuoke7, Damian Chukwu Odimegwu, Nnanna Collins Uzoma.
- Departemtn of Pharmaceutics, University of Nigeria, Nsukka.
- Department of Pharmaceutical Microbiology and Biotechnology, University of Nigeria, Nsukka.
- Department of Pharmaceutical Technology and Industrial Pharmacy, University of Nigeria, Nsukka.
- Department of Pharmaceutical Chemistry, University of Nigeria, Nsukka.
- Department of Pharmacology and Toxicology, University of Nigeria, Nsukka.
- Department of Computer and Robotics Education, University of Nigeria, Nsukka.
- Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Nsukka
| Key words:
Moringa oleifera, wound healing, phytochemical screening, herbal cream formulation.
*Corresponding Author: audu.momoh@unn.edu.ng
Page No: 265-273
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AbstractThis study evaluated the wound-healing potential of creams formulated with Moringa oleifera aqueous leaf extract. Fresh leaves of Moringa oleifera were air-dried, powdered, and extracted using Soxhlet extraction. The resulting extract was screened for phytochemical constituents and incorporated into cream formulations at concentrations of 0.2, 0.4, and 0.6%. The wound healing efficacy of the creams was evaluated using an excision wound model in rats over a 12-day period. Wound contraction was monitored and recorded at intervals of 2 days. Phytochemical screening revealed the presence of alkaloids, saponins, flavonoids, tannins, carbohydrates, and reducing sugars. The formulated creams showed desirable physical characteristics, including smooth texture, pleasant smell, and good washability. In vivo wound-healing evaluation revealed that the 0.6% Moringa cream consistently produced the highest percentage of wound contraction across all time points, reaching a peak of 97.06% by Day 12. The 0.2 and 0.4% formulations also produced positive healing trends but at a slower rate. This study therefore shows that Moringa oleifera aqueous leaves extract have wound-healing potentials and can serve as a natural, safe, and cost-effective ingredient for topical formulations. |