Susceptibility Profiles of Multiple Antibiotic-Resistant Uropathogens to Eleagnine Compound Isolated from Chryophyllum albidum G. Don Holl (Sapotaceae) Seed Cotyledons


Trends in Natural Products Research

Susceptibility Profiles of Multiple Antibiotic-Resistant Uropathogens to Eleagnine Compound Isolated from Chryophyllum albidum G. Don Holl (Sapotaceae) Seed Cotyledons.

Michael Oluwole Osungunna, Thomas Oyebode Idowu, Florence Olubunmi Akinwumi, Deborah Ifeoluwa Onifade

  1. Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Nigeria.
  2. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Nigeria.

 

Key words:

Eleagnine, uropathogens, Chryophyllum albidum, multiple antibiotic-resistantt.

 

*Corresponding Author: mowole@oauife.edu.ng
DOI:https://doi.org/10.61594/tnpr.v7i3.2026.175

 

Page No: 283-297
Volume: 7, Issue 3, 2026
Trends in Natural Products Research
Copy Right: NAPREG

 

 

 

Abstract

Persistent and recurrent urinary tract infections (UTIs) have been attributed to uropathogens developing resistance to multiple antibiotics. This has led to a rise in morbidity and mortality, treatment costs, hospital stays, and hospital visits, and has made the quest for more potent plant-derived antimicrobials unavoidable. The purpose of this study was to assess the susceptibility of various antibiotic-resistant uropathogens to eleagnine isolated from the seed cotyledon of Chryophyllum albidum. Using standard microbiological techniques, 100 uropathogens were isolated from urine samples of patients presented with UTIs at a Teaching Hospital Complex of a tertiary university in southwestern Nigeria. The isolates were identified using chromogenic agar and authenticated using conventional biochemical tests. Susceptibility profiles of the isolates to 12 selected commonly used antibiotics were determined using the Kirby-Bauer disk diffusion method. Susceptibility profiles of the multiple antibiotic-resistant uropathogens to eleagnine were determined using the broth microdilution technique. The results revealed Staphylococcus aureus as the predominant isolate with 72% occurrence. Susceptibility was highest for Levofloxacin (98%), and resistance was highest for meropenem. Also, the majority (81%) of the uropathogens have a multiple antibiotic resistance (MAR) index ≥ 0.2. All the multiple antibiotic-resistant uropathogens tested were susceptible to eleagnine with MIC50 of 0.625 mg/mL and MIC90 of 2.5 mg/mL. The study concluded that eleagnine exhibits antibacterial activity against multiple antibiotic-resistant uropathogens and may be effective in the management of recurrent and persistent urinary tract infections.