Evaluation of Anti-Inflammatory Activity of Methanol Leaf Extract of Detarium senegalense (J.F.Gmel) in Wistar rats


Evaluation of Anti-Inflammatory Activity of Methanol Leaf Extract of Detarium senegalense (J.F.Gmel) in Wistar rats

Fatima Mika’il Usman1, Tijjani Hassan Darma2, Abdullahi Rabiu Abubakar3,

  1. Department of Physics, Faculty of Sciences, Federal University, Dutse.
  2. Department Physics, Faculty of Physical Sciences, Bayero University, Kano.
  3. Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Bayero University, Kano.

 


 

Key words:

Anti-inflammatory, Paw edema, Carrageenan, Detarium senegalense, wistar rat.

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*Corresponding author:

raabdullahi.pha@buk.edu.ng or unisza7@gmail.com
+2349028774761
DOI: 10.48245/tnpr-2734391.2021.2.209

Page No.: 84-89

Volume: 2, Issue 2 2021

Trends in Natural Products Research

Copy Right: NAPREG

Abstract
Detarium senegalense (J.F. Gmelin) commonly known as Tallow tree (Family, Fabaceae). In Nigeria, it is called Taura (Hausa), Ogbogbo (Yoruba), Ofor (Igbo). The study evaluated the anti-inflammatory activity of methanol extract of Detarium senegalense in rats. The phytochemical screening was conducted using standard protocols. Acute toxicity testing was carried out according to the OECD guidelines 420. Anti-inflammatory testing in rat was conducted by administering distilled water 1 ml/kg to group I rats, a standard drug (Piroxicam) 10 mg/kg to group II, and group III-V rats received 25, 50 and 100 mg/kg of methanol extract of Detarium senegalese (DS). Thirty minutes later an acute inflammation was induced by injecting 0.1ml (1 %) carrageenan into plantar surface of rat hind paw. The Detarium senegalense crude methanol extract (DSME) contains alkaloids, flavonoids, saponins, tannins and triterpenes. The Median Lethal Dose (LD50) of DS was found to be above 2000mg/kg. In this test, DS 25, 50 and 100 mg/kg produced statistically significant (p < 0.05) decreased in the carrageanan-induced paw edema at 2 hours compared to D/W treated group. Also, the standard drug piroxicam 10mg/kg produced statistically significant (p < 0.05) decreased in the carrageanan-induced paw edema at 2 hours compared to D/W treated group. Detarium senegalense methanol extract possess anti-inflammatory activity and can be used for the development of herbal medicine for the treatment of inflammatory diseases. The crude extract should be fractionated and further tested using more anti-inflammatory models.