Evaluation of Dacryodes edulis Cream Formulations Against Some Causative Agents of Skin Infection


Evaluation of Dacryodes edulis Cream Formulations Against Some Causative Agents of Skin Infection

Babalola Sunday Aponjolosun1, Tolulope Omolola Ajala2* and Taiye Remi Fasola3

  1. Department of Microbiology and Biotechnology, Ajayi Crowther University, Oyo, Nigeria.
  2. Department of Pharmaceutics and Industrial Pharmacy, University of Ibadan, Ibadan, Nigeria.
  3. Department of Botany, Faculty of Science, University of Ibadan, Ibadan, Nigeria.

 
 

Keywords; Dacryodes edulis, Creams, Physicochemical, antimicrobial, Toxicity

 

 

 

 

*Corresponding author: tolulola1721@gmail.com;

DOI: https://doi.org/10.61594/tnpr.v5i2.2024.105

Page No: 51-65
Volume:5, Issue 2, 2024
Trends in Natural Products Research
Copy Right: NAPREG

           Abstract

Dacryodes edulis is traditionally used in treating skin infections, wounds, parasitic worms, acute malaria, elephantiasis, and as an astringent. The global integration of medicinal plants into new pharmaceutical products is significantly increasing for improved health and wellbeing of man. This study formulated creams from the leaf extract of D. edulis following standard procedures and assessed the organoleptic properties, density, extruding time, spreading time, pH, diffusion rate, globule size, viscosity, antimicrobial, stability, and sub-acute toxicity using mice. The smooth formulated creams vary from light green to dark green in colour with density of 0.90 ± 0.02 to 0.95 ± 0.02 g/cm3, extruding time of 5.57 ± 0.64 to 5.87 ± 0.78 sec, spreading time of 6.09 ± 0.07 to 7.49 ± 0.05 sec, pH of 3.46 ± 0.09 to 4.52 ± 0.08, diffusion rate of 1.58 to 3.33 mm/hr, globule size of 29.12 ± 15.00 to 53.21 ± 35.02 μm, and viscosity of 360.00 ± 16.33 to 1815.00 ± 148.49 mPa-s. The microbial inhibition zones (mm) were 11.0 ± 1.0 to 27.0 ± 1.0 for bacteria and 15.7 ± 0.6 to 22.0 ± 2.0 for fungi. The creams were stable at a lower temperature (29 ± 4 oC) for 120 days. The skin of the mice showed no oedema or erythema when the cream formulations were applied. FDe1 had completely acceptable physicochemical properties, active against some microorganisms causing skin infections, and could be improved for commercial application.