Evaluation of the Sub-Chronic Toxicity of Anacardium occidentale (Cashew) Leaves on Hepatic Function Indices in Albino Rats


Evaluation of the Sub-Chronic Toxicity of Anacardium occidentale (Cashew) Leaves on Hepatic Function Indices in Albino Rats

Omodamiro Olorunsola Dave1*, Ajah Obinna1, Jimoh Mulikat Abiola2 and Ewa-ibe Chigozie1

1.Pharmacology unit, Department of Biochemistry, Michael Okpara University of Agriculture, Umudike. Umuahia Abia State.

2.Department of Plant Biology, Osun State University, Osogbo.

 


 

Key words:

Hepatotoxicity, Anacardium occidentale, sub-chronic, hepatic cells

 

 

 

 

 

 

 

*Corresponding author:

majekdamiro@yahoo.com;

+2347064868550

DOI: 10.48245/tnpr-2734391.2021.1.206

Page No.: 117-125
Volume: 1, Issue 2, 2020
Trends in Natural Products Research
Copy Right: NAPREG

Abstract
The liver plays a central role in the metabolism and clearing of chemicals from the body and as such is susceptible to the toxicity from these agents. This present study evaluated the sub-chronic toxicity of methanol extract of Anacardium occidentale leaves on the liver of albino rats. Thirty (30) adult albino rats were randomly divided into five groups of 6 rats per group. Group 1 (normal control) received commercial rat feed and water, groups 2-5 received between 125-1000 mg/kg of leaf extract of A. occidentale. The treatment lasted for 21 days with weekly evaluation of biomarkers of liver toxicity. There was a significant (p < 0.05) increase in serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total and conjugate bilirubin of 1000 mg/kg extract treated rats when compared to the normal control up to the 3rd week. The histopathological study revealed mild portal inflammation without steatosis in the groups that received 1000 mg/kg. Therefore, these results suggested that methanol leaf extracts of A. occidentale could possess hepatotoxic properties at high dose after a long administration.