Flavonoids and the Mechanisms of their Anticancer Effects
Ikechukwu Peter1*, Theophine Akunne1, Samson Amos2, Peter Akah1
1Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka 410001, Enugu State, Nigeria.
2 School of Pharmacy, Cedarville University, Cedarville, USA.
Key words:
Anticancer activity, flavonoids, herbal remedy, polyphenolic compounds. .
*Corresponding author: 08069645175 DOI: 10.48245/tnpr-2734391.2021.2.101 Page No.: 1-12 Volume: 2, Issue 1 2021 Trends in Natural Products Research Copy Right: NAPREG |
Abstract A group of plant secondary metabolites are flavonoids, which are polyphenolic compounds. The predominant dietary intake forms of flavonoids are fruits, vegetables, plant-based beverages such as wine, green tea and cocoa-based foods. Many plants and spices produce flavonoids that are being widely utilized in herbal remedies since earlier civilization. A vast range of pharmacological action, including anticancer activities, is known for flavonoids. Signal transduction mechanisms linked to cellular proliferation, differentiation, apoptosis, inflammation, angiogenesis, metastasis and reversal of multidrug resistance have been documented. They also impede cancer onset, propagation and advancement by altering various enzymes and receptors. Flavonoids are now being researched for their possible anticancer activities due to their various molecular modes of action. Through offering insights into dietary origins, metabolism and molecular pathways, and their essential protein interactions, the current review highlights the remedial possibilities of flavonoids as agents against cancer. |