Sub-acute Effects of Methanol Extract of Acalypha godseffiana on Hematological and Lipid Profiles of Albino Rats.
Gladys Chinelo Ezeh¹, Christian Anene Ozioko², Samuel Okwudili Onoja³*, Patrick Emeka Aba4 Ruth Ndidiamaka Opara5, Yusuf Ndukaku Omeh5, Maxwell Ikechukwu Ezeja3, Aruh Otta Anaga4
- Department of Agriculture, Alex Ekwueme Federal University Ndufu Alike-Ikwo, Ebonyi State, Nigeria.
- Department of Veterinary Microbiology, Michael Okpara University of Agriculture Umudike, Abia State, Nigeria
- Department of Veterinary Physiology and Pharmacology, Michael Okpara University of Agriculture Umudike, Abia State, Nigeria.
- Department of Veterinary Physiology and Pharmacology, University of Nigeria, Nsukka, Enugu State, Nigeria
- Department of Biochemistry, Michael Okpara University of Agriculture Umudike, Abia State, Nigeria.
| Key words:
Acalypha godseffiana, hematology, hypolipidemia, toxicity test. .
*Corresponding author: onoja.samuel@mouau.edu.ng +2348030613032 Page No.: 30-36 Volume: 2, Issue 1 2021 Trends in Natural Products Research Copy Right: NAPREG |
Abstract This study aimed to investigate the effects of methanol extract of Acalypha godseffiana on hematological and lipid profile of albino rats. Cold maceration method was used in the preparation of the extract with 80 % methanol. Up and down method with dose limit of 2000 mg/kg was adopted in the oral acute toxicity test. Twenty-four (24) albino Wistar rats were randomly assigned to 4 groups (A–D, n = 6). Group A (control) received distilled water, while groups B-D received 100, 200 and 400 mg/kg of the extract, respectively. The rats were dosed once daily for 21consecutive days and weighed weekly. Twenty-four hours after the last treatment on day 21, the rats were fasted overnight and blood was collected into EDTA and plain bottles for hematology and serum preparation respectively. Manual method was used to determine the full blood cell count, while Randox kit was used to estimate the serum lipid profile spectrophotometrically. The extract was tolerated by the rat. The extract (200 mg/kg) treated group had reduced weight gain (p > 0.05) relative to the control group. The extract at 200 mg/kg increased (p < 0.05) the packed cell volume, hemoglobin concentration and red cell count in the treated groups when compared with the control group. The extract reduced (p < 0.05) the serum cholesterol and triglyceride levels when compared with the control group. The study suggests that methanol extract of Acalypha godseffiana have hypolipidemic and hematopoietic properties which justify its use in traditional medicine for this purpose. Sub-acute Effects of Methanol Extract of Acalypha godseffiana on Hematological and Lipid Profiles of Albino Rats Gladys Chinelo Ezeh1, Christian Anene Ozioko2, Samuel Okwudili Onoja3*, Patrick Emeka Aba4, Ruth Ndidiamaka Opara5, Yusuf Ndukaku Omeh5, Maxwell Ikechukwu Ezeja3, Aruh Otta Anaga4 1Department of Agriculture, Alex Ekwueme Federal University Ndufu Alike-Ikwo, Ebonyi State, Nigeria. 2Department of Veterinary Microbiology, Michael Okpara University of Agriculture Umudike, Abia State, Nigeria 3Department of Veterinary Physiology and Pharmacology, Michael Okpara University of Agriculture Umudike, Abia State, Nigeria 4Department of Veterinary Physiology and Pharmacology, University of Nigeria, Nsukka, Enugu State, Nigeria 5Department of Biochemistry, Michael Okpara University of Agriculture Umudike, Abia State, Nigeria |