Towards harnessing the Therapeutic Potential of Kolaviron, a Biflavonoid Complex from Garcinia kola Heckl: A Review of its Bioactivity and Mechanisms of Action

*Corresponding author: chukwuemeka.nworu@

oliviauniversity.com

DOI: 10.48245/tnpr-2734391.2023.4.101

Page No: 1-27
Volume:4, Issue 1, 2023
Trends in Natural Products Research
Copy Right: NAPREG

Abstract

Kolaviron, a bioactive biflavonoid complex found in the seeds of Garcinia kola, exhibits numerous therapeutic potentials. This paper provides an extensive review of the medicinal properties of kolaviron, and its significance in alternative medicine and drug development. The literatures on electronic databases, such as PubMed, Scopus, Web of Science, and Google Scholar, were thoroughly searched and analysed. The search keywords included “Kolaviron,” “Garcinia kola,” “bioactivity,” and “therapeutic uses”. The inclusion criteria for studies were those that investigated the bioactivity, safety, pharmacokinetics, and therapeutic potentials of kolaviron in preclinical (in vitro and in vivo) or clinical trials. The action mechanisms underlying the bioactivity of kolaviron have been partly elucidated. It modulates various signaling pathways involved in oxidative stress, inflammation, and cancer progression. Kolaviron was found to target multiple molecular targets and key transcription factors that regulate antioxidant defense systems or play crucial roles in immunoinflammatory pathways. In conclusion, this review highlights the therapeutic potential of kolaviron, emphasizing its diverse bioactivities such as antioxidant, anti-inflammatory, antimicrobial, antidiabetic and anticancer properties. These properties make it a promising candidate for the development of new therapeutic agents. However, further translational research is warranted to fully understand and harness its possible wide-ranging clinical applications.